Contact allergy to fragrances: current patch test results (2005-2008) from the Information Network of Departments of Dermatology.

BACKGROUND Contact sensitization to fragrances is common both in clinical and in population samples. The spectrum of allergens is broad and diverse, and to some extent covered by a set of screening agents. OBJECTIVES To examine the current frequency of contact sensitization to fragrance allergens in patients routinely patch tested for suspected allergic contact dermatitis with the baseline series and special series. PATIENTS AND METHODS Between 2005 and 2008, 40 709 patients were patch tested in the departments of the Information Network of Departments of Dermatology (http://www.ivdk.org). Results with selected fragrances were analysed. RESULTS Of all patients tested with the German baseline series, 15.1% reacted positively to fragrance mix (FM) I (6.6% positive), FM II (4.6% positive) or Myroxylon pereirae resin (balsam of Peru, 6.8% positive). Among the single constituents of FM I, Evernia prunastri [oak moss absolute (abs.)] was the leading allergen, and amyl cinnamal the least frequent allergen. Among fragrances not included in FM I or FM II, Evernia furfuracea (tree moss abs.) was the most common allergen. CONCLUSIONS For diagnostic purposes, it is necessary to combine several screening agents. The frequency of contact sensitization differs greatly between single fragrances.